喉炎宁口服液治疗急慢性咽喉炎的药效学研究
喉炎宁口服液,,喉炎宁口服液；抗炎作用；抗过敏作用；镇痛作用,1实验材料,2方法与结果,3讨论,参考文献
摘要：目的：研究喉炎宁口服液的主要药效学,为其临床应用提供理论依据。方法：采用二甲苯致小鼠耳廓肿胀、冰醋酸致小鼠腹腔毛细血管通透性亢进、小鼠棉球肉芽肿实验，考察喉炎宁的抗炎作用；采用大鼠被动皮肤过敏和2，4-二硝基氯苯致小鼠迟发性超敏反应实验，考察喉炎宁的抗过敏作用；用小鼠醋酸扭体法观察喉炎宁的镇痛作用。结果：喉炎宁口服液可明显减轻小鼠耳廓肿胀度、抑制腹腔毛细血管通透性增高、棉球肉芽组织增生；显著抑制大鼠被动皮肤过敏反应、小鼠迟发性超敏反应；减少醋酸所致小鼠扭体反应次数。结论：喉炎宁口服液有助于急、慢性咽喉炎临床症状的改善。关键词：喉炎宁口服液；抗炎作用；抗过敏作用；镇痛作用
Pharmacodynamic Study of Houyanning Oral Liquid on Acute and Chronic Faucitis
LIU Qin1, LIU Weirong2
(1.Medical School, Huangshi College of Science and Technology, Hubei 435000, China; 2.Department of Otolaryngology, Central Hospital of Huangshi ,Huangshi,Hubei 435000, China)
Abstract:Objective:To study the main pharmacodynamics of Houyanning oral liquid in order to provide theoretical basis on its clinical application.Methods:Ear edema induced by dimethylbenzene, abdominal capillary permeability by acetic acid and cotton-pill-implantation-induced hyperplasia in mice were used to study the anti-inflammatory effects; passive cutaneous anaphylaxis in rat and delayed type hypersensitivity induced by 2,4-nitrylchlorobenzene in mice were used to study the antiallergic effect; acetic acid-induced writhing test in mice were used to study the abirritation.Results:Houyanning oral liquid significantly suppressed xylene-induced ear edema, abdominal capillary permeability, cotton induced rat hyperplasia, and markedly inhibited passive cutaneous anaphylaxis in rat and delayed type hypersensitivity induced by 2,4-nitrylchlorobenzene in mice; the writhing times of mice induced by acetic acid decreased.Conclusion:Houyanning oral liquid is effective in clinical treatment on acute and chronic faucitis. ......
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