摘要：目的研究养心调肝益肾煎剂和调节“心-肝-肾”生殖轴对去势雄鼠性活动、阴茎海绵体内皮细胞一氧化氮(NO)含量的影响。方法手术去势造模，造模后第8天对不同实验组分别灌喂生理盐水(NS)、养心调肝益肾煎剂(YXTGYS)、男宝(Nanbao)混悬液，用药21 d后观察去势雄鼠的性活动，并测定去势雄鼠阴茎海绵体内皮细胞NO的含量。结果男宝组与去势对照组及正常对照组之间的嗅舔次数、爬背次数及NO含量比较无显著性差异；养心调肝益肾煎剂1、2组之间的嗅舔次数、爬背次数及NO含量比较也无显著性差异，但明显高于男宝组的嗅舔次数、爬背次数及NO含量(P<0.05)；养心调肝益肾煎剂1(或2)组各项指标均明显高于去势对照组，两者之间有显著性差异(P<0.05)；养心调肝益肾煎剂2组各项指标还明显高于正常对照组，两者之间有显著性差异(P<0.05)。结论 养心调肝益肾煎剂调节阴茎勃起功能的疗效明显优于男宝。

    关键词：养心调肝益肾煎剂； 去势雄鼠； 性活动； 阴茎海绵体内皮细胞； 一氧化氮

    Effects of YXTGYS Decoction on Sexual Activity and NO Content of Penis in Castrated Male Rats

    HUANG Xue-kuan, REN Ling-yan, LI Jin, DAI Xing-bi, HAN Zhi-gang, SHEN Qing, LIU Yang,

    (College of TCM, Chongqing University of Medical Sciences, Chongqing 400050，China)

    Abstract：ObjectiveTo investigate the effects of YXTGYS Decoction and adjusting heart-liver-kidney reproductive axis on sexual activity and NO content of endothelium cell of penial corpus cavernosum in the castrated male rats.MethodsOn the 8th day after making castrated model rats by operation，we respectively fed NS，YXTGYS，Nanbao mixed liquid into the stomaches of the different groups of male rats for 21 days. Afterwards ......